Superparamagnetic Iron Oxide Nanoparticles Boost Dendritic‑Cell Cross‑Presentation, Migration, and IL‑1β‑Mediated Adjuvant Activity
Abstract
Superparamagnetic iron oxide nanoparticles (SPIO) were synthesized and tested as carriers for antigen delivery into dendritic cells (DCs). SPIO‑laden DCs showed excellent biocompatibility and enhanced ovalbumin (OVA) cross‑presentation. We prepared positively charged SPIO/A⁺ (APTS‑coated) and negatively charged SPIO/D⁻ (DMSA‑coated) to assess how surface charge influences DC function and interleukin‑1β (IL‑1β) secretion. SPIO/A⁺ outperformed SPIO/D⁻ in promoting antigen cross‑presentation, T‑cell activation, and DC migration to secondary lymph nodes, likely via controlled IL‑1β release. These findings inform nanoadjuvant design for DC‑based vaccines and human immunotherapy.
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